2. Signaling Pathways
  3. GPCR/G Protein
  4. Adenylate Cyclase

Adenylate Cyclase

Adenylyl cyclase

Adenylate Cyclase

Related Products

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Adenylyl cyclases (ACs) are enzymes that catalyze the production of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). Adenylyl cyclases integrate positive and negative signals that act through G protein-coupled cell-surface receptors with other extracellular stimuli to finely regulate levels of cAMP within the cell. Humans express nine isoforms of membranous ACs and a soluble AC.

Based on regulatory properties, transmembrane ACs are classified into four groups: Group I: Ca2+/calmodulin-stimulated AC1, AC3, AC8; Group II: Gβγ-stimulated and Ca2+-insensitive AC2, AC4, AC7; Group III: Gαi/Ca2+/PKA-inhibited AC5, AC6; Group IV: forskolin/Ca2+/Gβγ-insensitive AC9. The soluble AC, unlike the transmembrane ACs, is insensitive to hormones, G proteins and forskolin, a diterpene extracted from the root of the plant Coleus forskohlii that directly activates all isoforms of transmembrane ACs except AC9.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P3647A
    [DPro10] Dynorphin A (1-11), porcine hydrochloride
    		Inhibitor
    [DPro10] Dynorphin A (1-11), porcine hydrochloride, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine hydrochloride has analgesic property.
    [DPro10] Dynorphin A (1-11), porcine hydrochloride
  • HY-135878R
    2',5'-Dideoxyadenosine (Standard)
    		Inhibitor
    2',5'-Dideoxyadenosine (Standard) is the analytical standard of 2',5'-Dideoxyadenosine. This product is intended for research and analytical applications. 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart.
    2',5'-Dideoxyadenosine (Standard)
  • HY-111985
    Revospirone
    		Inhibitor
    Revospirone (BAY Vq 7813) is a partial agonist of the 5-HT1A receptor with a Ki of 2 nmol/L. Revospirone inhibits adenylate cyclase activity with an IC50 of 124 nmol/L.
    Revospirone
  • HY-B1124AR
    Fipexide hydrochloride (Standard)
    		Inhibitor
    Fipexide (hydrochloride) (Standard) is the analytical standard of Fipexide (hydrochloride). This product is intended for research and analytical applications. Fipexide hydrochloride, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide hydrochloride reduces striatal adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide hydrochloride is used for senile dementia research. Fipexide hydrochloride acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection.
    Fipexide hydrochloride (Standard)
  • HY-134373A
    Bis-Cl-ANT-ATP tetrasodium
    		Inhibitor
    Bis-Cl-ANT-ATP (tetrasodium) is a fluorescent ATP derivative, which undergo spontaneous isomerization. Bis-Cl-ANT-ATP (tetrasodium) selectively inhibits B. pertussis Adenylyl Cyclase (AC) toxin CyaA over mammalian AC1, AC2, and AC5 (Kis = 16, 1,700, 2,400, and 1,600 nM, respectively). Bis-Br-ANT-ATP (tetrasodium) can be used in the study of whooping cough.
    Bis-Cl-ANT-ATP tetrasodium
  • HY-131776
    2-Chloro-ADP
    		Inhibitor
    2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) sis a Adenosine 5'-diphosphate (ADP; HY-W010918) derivative that induces human platelet aggregation and inhibits stimulated adenylate cyclase. 2-Chloro-ADP inhibits mortalin nucleotide-binding domain (NBD) with a Ki of 45.05 μM.
    2-Chloro-ADP
  • HY-126055A
    Hadacidin sodium
    		Inhibitor
    Hadacidin sodium is a competitive inhibitor of adenylate synthase. Hadacidin sodium binds to the active site of adenylate synthase, competitively inhibiting L-aspartate binding. Hadacidin sodium can be used in drug design, to help develop new inhibitors or activators to regulate adenylate synthase activity, and to play a role in the study of related diseases.
    Hadacidin sodium
  • HY-161021
    AC2 selective-IN-1
    AC2 selective-IN-1 (compound 14) is a? potent (IC50=4.45 μM), non-toxic, and selective mAC2 inhibitor.
    AC2 selective-IN-1
  • HY-19100
    ADX-10061
    		Antagonist
    ADX-10061 (compound NNC 687) is a dopamine D1 receptor antagonist with the Ki values of 9.1 nM, 5.8 nM, > 10 000 nM and 355 nM for adenylyl cyclase, D1, D2 and 5-HT2 receptor, respectively. ADX-10061 can be used for study of schizophrenia.
    ADX-10061
  • HY-N15029
    Destomycin A
    		Activator
    Destomycin A is an aminoglycoside antibiotic with antibacterial (Gram-positive bacteria, Gram-negative bacteria), antifungal and anthelmintic activities. Destomycin A inhibits the polypeptide synthesis in cells of Escherichia coli and stimulation of adenylate cyclase in animal tissues.
    Destomycin A
  • HY-134372A
    Bis-Br-ANT-ATP tetrasodium
    		Inhibitor
    Bis-Br-ANT-ATP (tetrasodium) is a fluorescent derivative of adenosine-5’-triphosphate (ATP) (HY-B2176). Bis-Br-ANT-ATP (tetrasodium) selectively inhibits B. pertussis adenylyl cyclase toxin CyaA (Ki: 12.6 nM). Bis-Br-ANT-ATP (tetrasodium) can be used in Whooping cough research.
    Bis-Br-ANT-ATP tetrasodium
  • HY-B1124R
    Fipexide (Standard)
    		Inhibitor
    Fipexide (Standard) is the analytical standard of Fipexide. This product is intended for research and analytical applications. Fipexide, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide reduces striatal adenylate cyclase activity. Fipexide has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide is used for senile dementia research. Fipexide acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection.
    Fipexide (Standard)
  • HY-120547
    UCB-11056
    UCB-11056 is a modulator of cyclic AMP generation. UCB-11056 can rapidly increase cyclic AMP levels in the rat brain in vivo and potentiate stimulated cyclic AMP formation in vitro. UCB-11056 does not stimulate cAMP formation on its own. UCB-11056 is a potential nootropic drug.
    UCB-11056
  • HY-173215
    3-Dimethylaminopropyl deacetylforskolin
    		Activator
    3-Dimethylaminopropyl deacetylforskolin is a dehydro derivative of adenylate cyclase activator Forskolin (HY-15371) and may cause cross-immunoreactivity with anti-Forskolin antibodies.
    3-Dimethylaminopropyl deacetylforskolin
  • HY-155404
    Adenylyl cyclase-IN-1
    		Inhibitor
    Adenylyl cyclase-IN-1 is an adenylyl cyclase inhibitor with potential use in ocular hypotonia research.
    Adenylyl cyclase-IN-1
  • HY-100396R
    SQ22536 (Standard)
    		Inhibitor
    SQ22536 (Standard) is the analytical standard of SQ22536. This product is intended for research and analytical applications. SQ22536 is an effective adenylate cyclase (AC) inhibitor.
    SQ22536 (Standard)
Cat. No. Product Name / Synonyms Application Reactivity